Expression of melanocortin-4 receptor and agouti-related peptide mRNAs in arcuate nucleus during long term malnutrition of female ovariectomized rats

Authors

  • Aida Hematzadeh Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Ali Moghadam Biotechnology Institute, College of Agriculture, Shiraz University, Shiraz, Iran
  • Ali Niazi Biotechnology Institute, College of Agriculture, Shiraz University, Shiraz, Iran
  • Amin Tamadon Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Transgenic Te.chnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Fatemeh Sabet Sarvestani Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Maliheh Jahanara Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Reza Moghiminasr Department of Stem Cells and Developmental Biology at the Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
Abstract:

Objective: Melanocortin-4 receptor (MC4R) and agouti-related peptide (AgRP) are involved in energy homeostasis in the rat. The aim of the present study was to evaluate the expression of MC4R and AgRP mRNAs in arcuate nucleus (ARC) during long term malnutrition of female ovariectomized rats. Materials and Methods: Ten female ovariectomized rats were divided into two equal groups (n=6) of normal and restricted diet groups. Using real-time PCR, the relative expressions (compared to controls) of MC4R and AgRP mRNAs were compared between both diet groups. Results: The relative expression of MC4R and AgRP mRNA in the ARC of female ovariectomized rats during long term malnutrition was higher than those with normal diet (P

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Journal title

volume 18  issue 1

pages  104- 107

publication date 2015-01-01

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